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http://hdl.handle.net/11375/26587| Title: | Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada |
| Authors: | Sjaarda CP Guthrie JL Mubareka S Simpson JT Hamelin B Wong H Mortimer L Slinger R McArthur AG Desjardins M McGeer A Mazzulli T Douchant K Brabant-Kirwan D Fattouh R Campigotto A Patel SN Fittipaldi N Colautti RI Sheth PM |
| Keywords: | COVID-19;G614D;PANGOLIN lineage;SARS-CoV-2;epidemiology;genetics;infectious disease;public health;Base Sequence;COVID-19;Genetic Variation;Genome, Viral;Humans;Mutation Rate;Ontario;Phylogeny;SARS-CoV-2;Sequence Analysis, RNA;Spike Glycoprotein, Coronavirus |
| Publication Date: | 5-May-2021 |
| Publisher: | American Society for Microbiology |
| Abstract: | <jats:p>Genome-wide variation in SARS-CoV-2 reveals evolution and transmission dynamics which are critical considerations for disease control and prevention decisions. Here, we review estimates of the genome-wide viral mutation rates, summarize current COVID-19 case load in the province of Ontario, Canada (5 January 2021), and analyze published SARS-CoV-2 genomes from Ontario (collected prior to 24 November 2020) to test for more infectious genetic variants or lineages.</jats:p> |
| metadata.dc.rights.license: | Attribution - CC BY |
| Rights: | Attribution - CC BY This Creative Commons license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. Recommended for maximum dissemination and use of licensed materials. |
| URI: | http://hdl.handle.net/11375/26587 |
| metadata.dc.identifier.doi: | https://doi.org/10.1128/msphere.00011-21 |
| ISSN: | 2379-5042 2379-5042 |
| Appears in Collections: | Faculty Publications (via McMaster Experts) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canad.pdf | Published version | 937.94 kB | Adobe PDF | View/Open |
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