Drug release from polymer-coated TiO2 nanotubes on additively manufactured Ti-6Al-4V bone implants: a feasibility study

Abstract

Insufficient osseointegration, inflammatory response and bacterial infection are responsible for the majority of bone implant failures. Drug-releasing implants subjected to adequate surface modification can concurrently address these challenges to improve the success of implant surgeries. This work investigates the use of Ti-6Al-4V (Ti64) with a dual-scale surface topography as a platform for local drug delivery. Dual-scale topography was obtained combining the inherent microscale roughness of the Ti64 samples manufactured by selective laser melting (SLM) with the nanoscale roughness of TiO2 nanotubes (TNTs) obtained by subsequent electrochemical anodization at 60 V for 30 min. TNTs were loaded with a solution of penicillin-streptomycin, a common antibiotic, and drug release was tested in vitro. Three biocompatible and biodegradable polymers, i.e. chitosan, poly(ε-caprolactone) and poly(3-hydroxybutyrate), were deposited by spin coating, while preserving the microscale topography of the substrate underneath. The presence of polymer coatings overall modified the drug release pattern, as revealed by fitting of the experimental data with a power-law model. A slight extension in the overall duration of drug release (about 17% for a single layer and 33% for two layers of PCL and PHB) and reduced burst release was observed for all polymer-coated samples compared to uncoated, especially when two layers of coatings were applied.