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Adaptive Reductions in Left Ventricular Diastolic Compliance Protect the Heart From Stretch-Induced Stunning

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dc.contributor.authorWeil BR
dc.contributor.authorTechiryan G
dc.contributor.authorSuzuki G
dc.contributor.authorKonecny F
dc.contributor.authorCanty JM
dc.contributor.departmentSurgery
dc.date.accessioned2021-10-15T14:53:04Z
dc.date.available2021-10-15T14:53:04Z
dc.date.issued2019-08
dc.date.updated2021-10-15T14:53:01Z
dc.description.abstractSwine subjected to 2 weeks of repetitive pressure overload (RPO) exhibited significant myocyte loss, but left ventricular (LV) systolic function was preserved, and chamber dilatation did not occur. Instead, myocardial remodeling characterized by myocyte hypertrophy and interstitial fibrosis led to a marked reduction in LV diastolic compliance, which protected the heart from stretch-induced myocyte injury and preserved LV ejection fraction without anatomic LV hypertrophy. These results support a novel paradigm that links cardiac adaptations to RPO with the pathogenesis of reduced LV diastolic compliance and may explain how LV stiffening can occur in the absence of sustained hypertension or anatomic hypertrophy.
dc.identifier.doihttps://doi.org/10.1016/j.jacbts.2019.04.002
dc.identifier.issn2452-302X
dc.identifier.issn2452-302X
dc.identifier.urihttp://hdl.handle.net/11375/27067
dc.publisherElsevier BV
dc.subjectBP, blood pressure
dc.subjectEDPVR, end-diastolic pressure−volume relationship
dc.subjectHFpEF, heart failure with preserved ejection fraction
dc.subjectLV, left ventricular
dc.subjectLVEDP, left ventricular end-diastolic pressure
dc.subjectLVEDV, left ventricular end-diastolic volume
dc.subjectPE, phenylephrine
dc.subjectPV, pressure−volume
dc.subjectRPO, repetitive pressure overload
dc.subjectTUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling
dc.subjectcTnI, cardiac troponin I
dc.subjectdiastolic dysfunction
dc.subjectfibrosis
dc.subjectheart failure
dc.subjectmyocardial stunning
dc.subjectstretch
dc.subjectΔEDP/ΔEDV, changes in end-diastolic pressure/end-diastolic volume
dc.titleAdaptive Reductions in Left Ventricular Diastolic Compliance Protect the Heart From Stretch-Induced Stunning
dc.typeArticle

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