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http://hdl.handle.net/11375/26601
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DC Field | Value | Language |
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dc.contributor.author | Hong J-M | - |
dc.contributor.author | Hu L-H | - |
dc.contributor.author | Zhong Q-S | - |
dc.contributor.author | Zhu L-C | - |
dc.contributor.author | Hang Y-P | - |
dc.contributor.author | Fang X-Y | - |
dc.contributor.author | Sun H-B | - |
dc.contributor.author | Huang Z-H | - |
dc.contributor.author | Xu J | - |
dc.contributor.author | Chen Y-H | - |
dc.date.accessioned | 2021-06-15T16:20:51Z | - |
dc.date.available | 2021-06-15T16:20:51Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.uri | http://hdl.handle.net/11375/26601 | - |
dc.description.abstract | Objectives: The 2019 novel coronavirus disease (COVID-19) pandemic is the biggest public health crises in the 21st century. While most patients infected with the COVID-19 virus have no to moderate symptoms, there is currently limited clinical information about these patients. Methods: In this study, we retrospectively investigated 41 patients infected with the COVID-19 virus in Nanchang, Jiangxi province, China, from February 4 to March 2, 2020. Nanchang is about 260 km southeast of Wuhan, the initial epicenter of the COVID-19 pandemic. We retrieved information on patient demographics, physical examination results, epidemiology, clinical manifestations, underlying conditions, laboratory analyses, radiological images, and treatment outcomes. Results: Most patients (70.7%) had a history of close contact with patients with confirmed COVID-19, and 16 patients (39.0%) showed a high degree of family clustering. All 41 patients had no to moderate symptoms. The median age was 39.9 years and common symptoms of illness were fever (69.2%), cough (65.4%), and fatigue (19.2%). The dominant patient group was middle-aged women, with hypertension (14.6%) and chronic liver disease (12.2%) as the most frequent underlying conditions. All patients recovered, with the mean time of viral nucleic acid clearance at 10.6 days. Chest CT scans presented ground-glass opacities in 53.7% of patients while 26.8% had normal CT images. Laboratory results showed that lymphocyte counts, lymphocyte percentages, ESR, CRP, IgG, Fib, and cytokines were correlated to patients' conditions. Approximately 60-90% of patients had abnormally high levels of cytokines IL-4, IL-6, IL-10, and/or TNF-α. Conclusions: Our results showed variable clinical and laboratory presentations among this group of patients infected with the COVID-19 virus. Though all 41 patients recovered, our results suggest that cytokine levels and other biochemical indicators should be monitored for patients infected with the COVID-19 virus showing no to moderate symptoms to ensure quick access for critical medical attention, if needed. | - |
dc.publisher | Frontiers Media SA | - |
dc.rights | Published source must be acknowledged with citation Copyright must be acknowledged First publication by Frontiers Media must be acknowledged Must link to published article | - |
dc.rights.uri | 2 | - |
dc.subject | COVID-19 | - |
dc.subject | asymptomatic | - |
dc.subject | biochemical & physiological biomarkers | - |
dc.subject | close contact | - |
dc.subject | cytokines | - |
dc.subject | epidemiogy | - |
dc.title | Epidemiological Characteristics and Clinical Features of Patients Infected With the COVID-19 Virus in Nanchang, Jiangxi, China | - |
dc.type | Article | - |
dc.date.updated | 2021-06-15T16:20:50Z | - |
dc.rights.license | Attribution - CC BY | - |
dc.identifier.doi | https://doi.org/10.3389/fmed.2020.571069 | - |
Appears in Collections: | Faculty Publications (via McMaster Experts) |
Files in This Item:
File | Description | Size | Format | |
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Epidemiological Characteristics and Clinical Features of Patients Infected With the COVID-19 Virus in Nanchang, Jiangxi, Chi.pdf | Published version | 444.37 kB | Adobe PDF | View/Open |
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