Genetic Analysis of Stress Response and Life Span Regulation in Caenorhabditis Nematodes
| dc.contributor.advisor | Gupta, Bhagwati | |
| dc.contributor.author | De, Atreyee | |
| dc.contributor.department | Biology | en_US |
| dc.date.accessioned | 2024-10-25T17:46:10Z | |
| dc.date.available | 2024-10-25T17:46:10Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | This thesis investigates the roles of the Axin homolog PRY-1 and the Insulin/IGF-1 signaling (IIS) pathways in Caenorhabditis nematodes to elucidate their influence on aging, stress responses, and metabolic regulation. Comparative analyses between C. elegans and C. briggsae highlight conserved and divergent genetic mechanisms within the IIS pathway that regulate lifespan and metabolic processes. Transcriptome profiling reveals novel genes downstream of the daf-2-daf-16 pathway, furthering our understanding of the underlying genetic networks. PRY-1, a key component of the Wnt signaling pathway, plays a significant role in regulating axis formation, lipid metabolism, neuron and vulva development, cell polarity, and lifespan. This research examines PRY-1’s interactions with BAR-1 (a β-catenin homolog), and how these interactions influence lipid metabolism, vitellogenin expression, lifespan, and vulva development. This work extends our understanding of the IIS and Wnt pathways, emphasizing these signaling axes' evolutionary importance in aging, metabolic regulation, and stress response. | en_US |
| dc.description.degree | Master of Science (MS) | en_US |
| dc.description.degreetype | Thesis | en_US |
| dc.description.layabstract | This thesis explores how specific biological pathways control aging and stress responses in two species of tiny roundworms, Caenorhabditis elegans and Caenorhabditis briggsae. The research focuses on two key pathways: the Insulin/IGF-1 signaling (IIS) pathway, which regulates lifespan and metabolism, and the PRY-1/Axin component of Wnt signaling pathway, which is crucial for regulating development and lifespan. The study aims to understand how these pathways influence stress response and lifespan and identify new molecular candidates functioning downstream of these pathways. These findings could provide new insights into the biological processes behind aging and help inform potential treatments for age-related diseases in humans. | en_US |
| dc.identifier.uri | http://hdl.handle.net/11375/30477 | |
| dc.language.iso | en | en_US |
| dc.subject | C. elegans | en_US |
| dc.subject | aging | en_US |
| dc.subject | stress response | en_US |
| dc.subject | lifespan | en_US |
| dc.title | Genetic Analysis of Stress Response and Life Span Regulation in Caenorhabditis Nematodes | en_US |
| dc.type | Thesis | en_US |