Radiosensitization of Anoxic Mammalian Cells

Abstract

<p>The purpose of the work described in this thesis was to (a) better understand the mechanisms of chemical radiosensitization of mammalian cells so that the most effective compounds may be selected for radiotherapeutic use, and (b) to possibly explain the failure of early attempts to sensitize mammalian cells in vivo using chemical radiosensitizers. The effect of triacetoneamine N-oxyl (TAN) and several electron-affinic compounds on the colony forming ability of mammalian cells irradiated at both high and low cell concentrations was studied. A possible mechanism of sensitization for TAN was proposed.</p>