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Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses

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Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.pdf (4.03 MB)

Date

2021-05

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Elsevier BV

Abstract

Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associated with manifestation of COVID-19 severity. In spite of progress in understanding how SARS-CoV-2 activates antiviral responses, mechanistic studies into wild-type SARS-CoV-2-mediated induction and inhibition of human type I IFN responses are scarce. Here we demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and in moderate cases of COVID-19. In vitro stimulation of type I IFN expression and signaling in human airway epithelial cells is associated with activation of canonical transcriptions factors, and SARS-CoV-2 is unable to inhibit exogenous induction of these responses. Furthermore, we show that physiological levels of IFNα detected in patients with moderate COVID-19 is sufficient to suppress SARS-CoV-2 replication in human airway cells.

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Immunology, Virology

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URI

http://hdl.handle.net/11375/26588

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Attribution-NonCommercial-NoDerivs - CC BY-NC-ND This license is the most restrictive of the main Creative Commons licenses, only allowing others to download your works and share them with others as long as they credit you, but they can?t change them in any way or use them commercially.
Except where otherwised noted, this item's license is described as Attribution-NonCommercial-NoDerivs - CC BY-NC-ND This license is the most restrictive of the main Creative Commons licenses, only allowing others to download your works and share them with others as long as they credit you, but they can?t change them in any way or use them commercially.