DNA Base Complexes of Platinum and the Antitumor Action of cis-Pt(NH₃)₂Cl₂
| dc.contributor.advisor | Lock, C.J.L. | en_US |
| dc.contributor.author | Sporanzini, Robert A. | en_US |
| dc.contributor.department | Chemistry | en_US |
| dc.date.accessioned | 2014-06-18T16:53:57Z | |
| dc.date.available | 2014-06-18T16:53:57Z | |
| dc.date.created | 2009-12-22 | en_US |
| dc.date.issued | 1980-06 | en_US |
| dc.description.abstract | <p>A previously unknown mode of binding of platinum complexes to the DNA bases is described. The binding mode is characteristic of cis and not trans-Pt(NH₃)₂Cl₂ and is thought to be related to the ability of cis compounds to form hydroxobridged dimers. It is suggested that the differing anticancer activity of cis and trans-Pt(NH₃)₂Cl₂ may result from this difference in chemistry which is based on the differing stereochemical requirements of cis and trans isomers.</p> | en_US |
| dc.description.degree | Doctor of Philosophy (PhD) | en_US |
| dc.identifier.other | opendissertations/620 | en_US |
| dc.identifier.other | 1979 | en_US |
| dc.identifier.other | 1098275 | en_US |
| dc.identifier.uri | http://hdl.handle.net/11375/11215 | |
| dc.subject | Chemistry | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | DNA Base Complexes of Platinum and the Antitumor Action of cis-Pt(NH₃)₂Cl₂ | en_US |
| dc.type | thesis | en_US |
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