Biological and Molecular Studies of a Low Oncogenic Mutant of Human Adenovirus Type 12

dc.contributor.advisor	Mak, Stanley	en_US
dc.contributor.author	Ezoe, Hisanori	en_US
dc.contributor.department	Biology	en_US
dc.date.accessioned	2014-06-18T17:05:41Z
dc.date.available	2014-06-18T17:05:41Z
dc.date.created	2009-08-20	en_US
dc.date.issued	1976	en_US
dc.description.abstract	<p>Physical and biological properties of a low oncogenic mutant (cyt mutant) of highly oncogenic human adenovirus type 12 were studied. The highly oncogenic parental strain contains much higher proportion of functionally defective particles than the cyt mutant. The role of defective virions was discussed in relation to oncogenicity of the viruses. Correlation of defectivity and viral DNA structure, as studied by electron microscopy, was made. Some defective virions have a specific deletion in their DNA. Also molecular mechanism for the reduction of virus yield by the cyt mutant was examined and it was found that the viral DNA synthesis was a limiting factor.</p>	en_US
dc.description.degree	Doctor of Philosophy (PhD)	en_US
dc.identifier.other	opendissertations/878	en_US
dc.identifier.other	1720	en_US
dc.identifier.other	955604	en_US
dc.identifier.uri	http://hdl.handle.net/11375/13946
dc.subject	Biology	en_US
dc.subject	Biology	en_US
dc.title	Biological and Molecular Studies of a Low Oncogenic Mutant of Human Adenovirus Type 12	en_US
dc.type	thesis	en_US

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