The Distribution of Manganese in Blood
| dc.contributor.advisor | Fritze, K. | |
| dc.contributor.author | Hancock, Ronald George Vincent | |
| dc.contributor.department | Chemistry | en_US |
| dc.date.accessioned | 2015-08-19T14:08:58Z | |
| dc.date.available | 2015-08-19T14:08:58Z | |
| dc.date.issued | 1970-09 | |
| dc.description.abstract | <p> The distribution of manganese in blood serum and erythrocytes has been investigated using a combination of radioactive tracer method with both gel chromatography and disc gel electrophoresis. </p> <p> In serum, there are two manganese-binding proteins. The first is a(beta)1 globulin with a molecular weight of 70,000. This forms a relatively labile manganese complex both in vitro and in vivo, and is remarkably similar in both its chromatographic and electrophoretic behaviour to the iron-binding protein, transferrin. The second protein is a higher molecular weight (beta) globulin. It is found to incorporate radiomanganese in vivo only, thereupon forming a very stable entity. </p> <p> In erythrocytes, manganese occurs predominantly in a porphyrin bound to apoglobin, giving rise to a species similar to hemoglobin . </p> | en_US |
| dc.description.degree | Doctor of Philosophy (PhD) | en_US |
| dc.description.degreetype | Thesis | en_US |
| dc.identifier.uri | http://hdl.handle.net/11375/17921 | |
| dc.language.iso | en | en_US |
| dc.subject | manganese, blood serum, erythrocytes, radioactive tracer method, gel chromatography, disc gel electrophoresis, labile manganese complex, vitro, in vivo | en_US |
| dc.title | The Distribution of Manganese in Blood | en_US |
| dc.type | Thesis | en_US |