The Under-Representation of Women in Randomized Controlled Trials of Heart Failure

Abstract

Women are thought to be under-represented as clinical trial participants and as clinical trialists in heart failure. We reviewed randomized controlled trials of heart failure published in high impact medical journals and examined the representation of women as both participants and authors. Furthermore, we explored clinical trial characteristics independently associated with women as clinical trial participants and as lead authors. Our analysis demonstrated that women are under-represented as both clinical trial participants and leaders, with no change in temporal trends over time. Addressing clinical trial characteristics associated with under-representation and developing strategies to overcome barriers may be a strategic way to improve the representation of women in heart failure research.