Exploring the effects of chronic vitamin C deficiency in a mouse model of Her2-positive breast cancer
| dc.contributor.advisor | Schellhorn, Herb | |
| dc.contributor.author | Kelly, Rachel | |
| dc.contributor.department | Biology | en_US |
| dc.date.accessioned | 2016-10-27T13:56:33Z | |
| dc.date.available | 2016-10-27T13:56:33Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Vitamin C (VC) is an antioxidant that humans must include in their diet to prevent scurvy. High intake of VC may reduce the incidence of some types of cancer, and high-dose intravenous VC is an alternative cancer therapy. In this study, we used a genetically modified mouse to model the effects of chronic VC deficiency in breast cancer. Mice were fed either a low-dose or normal-dose VC diet, and were monitored for cancer development. We found that there was no difference in tumour characteristics between the mice that received low-dose versus normal VC supplementation. The results of this study suggest that chronic VC deficiency may not have an effect in this specific type of breast cancer. | en_US |
| dc.description.degree | Master of Science (MSc) | en_US |
| dc.description.degreetype | Thesis | en_US |
| dc.identifier.uri | http://hdl.handle.net/11375/20745 | |
| dc.language.iso | en | en_US |
| dc.title | Exploring the effects of chronic vitamin C deficiency in a mouse model of Her2-positive breast cancer | en_US |
| dc.type | Thesis | en_US |