A Correlation of the Molecular Damage and Biological Functions of the Human Adenovirus Following UV and Gamma Irradiation

Abstract

<p> The expression of several different functions of the oncogenic human adenovirus type 12 and non-onconogenic human adenovirus type 2 were examined after infection of the human KB cells. Also, following UV and gamma irradiation of the virus, the molecular damage included in the viral DNA was correlated with the biological functions expressed by the radiation induced defective virus particles. The results were discussed in relation to the current ideas of viral oncogenesis ad the mechanism of radiation DNA damage and repair in other organisms.</p>