Aspects of Technetium Chemistry

Abstract

<p>Interest in technetium chemistry is derived from the fact that it is a recently-discovered element and from the use of technetium-99m as a radioactive label in diagnostic medicine. Compounds related to both sources of interest have been characterized by X-ray crystallography, vibrational spectroscopy and multinuclear nuclear magnet resonance spectroscopy.</p> <p>The crystal structure of a penicillamine complex of technetium consists of an oxotechnetium(V) core bonded to the S, N, and O atoms of one penicillamine moiety and the S and N atoms of a second. Further characterization, including tracer studies with ⁹⁹ᵐTc, indicate that this complex is identical to an hepatobiliary agent erroneously formulated as a technetium(IV) species. The crystal structure of an anionic catechol complex of technetium also contains the oxotechnetium(V) core and suggests that the technetium(IV) formulation for a number of other radio-pharmaceuticals is incorrect. The crystal structure determination of a complex containing the ethylenebis(2-mercaptoacetamide) ligand forms part of a larger program to design, systematically, new scanning agents.</p> <p>Technetium complexes involving cyanide ligands are shown to be similar to their rhenium analogs.</p> <p>Several new technetium(VII) species were synthesized and used to establish ranges for parameters in the nuclear magnetic resonance spectroscopy of ⁹⁹Tc.</p>