Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/28231
Title: | Mitonuclear interactions and the origin of macaque society |
Authors: | Zhu, Jianlong |
Advisor: | Evans, Ben |
Department: | Biology |
Keywords: | Macaca;female philopatry;dispersal;natural selection;behavior |
Publication Date: | 2023 |
Abstract: | In most eukaryotes, aerobic respiration requires interactions between autosomally- encoded genes (Ninteract genes) and mitochondrial DNA, RNA, and protein. In species where females are philopatric, contrasting distributions of genetic variation in mito- chondrial and nuclear genomes creates variation in mitonuclear interactions that may be subject to natural selection. To test this expectation, we turned to a group with extreme female philopatry: the macaque monkeys. We examined four genomic datasets from (i) wild caught and (ii) captive populations of rhesus macaque, which is the most widely distributed non-human primate, and (iii) the stump-tailed macaque and (iv) a subspecies of longtail macaque, both of whose mitochondrial DNA is introgressed from a highly di- verged ancestor. We identified atypically long runs of homozygosity, low polymorphism, high differentiation and/or rapid protein evolution associated with Ninteract genes com- pared to non-Ninteract genes. These metrics suggest a subset of Ninteract genes were independently subject to natural selection in multiple species. Selection on mitonuclear interactions is thus a factor in macaque genome evolution that could have influenced as- pects of macaque societies including species diversity, ecological breadth, female-biased adult sex ratio and demography, sexual dimorphism, and mitonuclear phylogenomics. |
URI: | http://hdl.handle.net/11375/28231 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Zhu_Jianlong_Dec2022_MSc.pdf | 12.47 MB | Adobe PDF | View/Open |
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