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http://hdl.handle.net/11375/26714
Title: | Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit |
Authors: | Alkhatib AH Dvorkin-Gheva A Szechtman H |
Department: | Psychiatry & Behavioural Neurosciences |
Keywords: | 8-Hydroxy-2-(di-n-propylamino)tetralin;Animals;Behavior, Animal;Brain;Compulsive Behavior;Disease Models, Animal;Dopaminergic Neurons;Drug Interactions;Male;Nerve Tissue Proteins;Neurons;Obsessive-Compulsive Disorder;Quinpirole;Random Allocation;Rats;Rats, Long-Evans;Serotonergic Neurons;Serotonin 5-HT1 Receptor Agonists;Serotonin 5-HT2 Receptor Agonists;Serotonin 5-HT3 Receptor Agonists;Serotonin Receptor Agonists;Spatial Behavior |
Publication Date: | Feb-2013 |
Publisher: | Ovid Technologies (Wolters Kluwer Health) |
Abstract: | This study investigated whether the serotonin 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) can induce compulsive checking in a large open field, as does the dopamine D2/D3 receptor agonist quinpirole. To induce compulsive checking, male rats were exposed to eight injections of either 8-OH-DPAT (1 mg/kg), quinpirole (0.2 mg/kg), or saline. Subsequently, to assess cross-sensitization, rats received an acute challenge of 8-OH-DPAT or quinpirole. The results showed that treatment with 8-OH-DPAT induces compulsive checking and may have a stronger effect on this behavior compared with quinpirole. However, there was no cross-sensitization between 8-OH-DPAT and quinpirole on measures of compulsive checking and locomotion. Moreover, the spatial distribution of locomotor paths in 8-OH-DPAT animals was more confined and invariant than in quinpirole rats; their rate of locomotor sensitization was also faster than that in quinpirole animals. Thus, although 8-OH-DPAT and quinpirole can induce compulsive checking in a large open field, the results suggest that they do so differently. It is suggested that 8-OH-DPAT and quinpirole probably produce compulsive behavior by acting on different parts of a security motivation circuit underlying obsessive-compulsive disorder. Quinpirole may induce compulsive checking behavior by directly driving dopaminergic activity mediating the motivational drive to check. Conversely, 8-OH-DPAT may perpetuate the activated motivational state by inhibiting the serotonergic-negative feedback signals that normally deactivate the obsessive-compulsive disorder circuit. |
metadata.dc.rights.license: | Attribution-NonCommercial - CC BY-NC |
Rights: | Attribution-NonCommercial - CC BY-NC |
URI: | http://hdl.handle.net/11375/26714 |
metadata.dc.identifier.doi: | https://doi.org/10.1097/fbp.0b013e32835d5b7a |
ISSN: | 0955-8810 1473-5849 |
Appears in Collections: | Psychiatry & Behavioural Neurosciences Publications |
Files in This Item:
File | Description | Size | Format | |
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Alkhatib_revised_2012-11-29.pdf | Submitted version | 766 kB | Adobe PDF | View/Open |
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