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http://hdl.handle.net/11375/26714
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DC Field | Value | Language |
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dc.contributor.author | Alkhatib AH | - |
dc.contributor.author | Dvorkin-Gheva A | - |
dc.contributor.author | Szechtman H | - |
dc.date.accessioned | 2021-08-10T19:32:15Z | - |
dc.date.available | 2021-08-10T19:32:15Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0955-8810 | - |
dc.identifier.issn | 1473-5849 | - |
dc.identifier.uri | http://hdl.handle.net/11375/26714 | - |
dc.description.abstract | This study investigated whether the serotonin 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) can induce compulsive checking in a large open field, as does the dopamine D2/D3 receptor agonist quinpirole. To induce compulsive checking, male rats were exposed to eight injections of either 8-OH-DPAT (1 mg/kg), quinpirole (0.2 mg/kg), or saline. Subsequently, to assess cross-sensitization, rats received an acute challenge of 8-OH-DPAT or quinpirole. The results showed that treatment with 8-OH-DPAT induces compulsive checking and may have a stronger effect on this behavior compared with quinpirole. However, there was no cross-sensitization between 8-OH-DPAT and quinpirole on measures of compulsive checking and locomotion. Moreover, the spatial distribution of locomotor paths in 8-OH-DPAT animals was more confined and invariant than in quinpirole rats; their rate of locomotor sensitization was also faster than that in quinpirole animals. Thus, although 8-OH-DPAT and quinpirole can induce compulsive checking in a large open field, the results suggest that they do so differently. It is suggested that 8-OH-DPAT and quinpirole probably produce compulsive behavior by acting on different parts of a security motivation circuit underlying obsessive-compulsive disorder. Quinpirole may induce compulsive checking behavior by directly driving dopaminergic activity mediating the motivational drive to check. Conversely, 8-OH-DPAT may perpetuate the activated motivational state by inhibiting the serotonergic-negative feedback signals that normally deactivate the obsessive-compulsive disorder circuit. | - |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | - |
dc.rights | Attribution-NonCommercial - CC BY-NC | - |
dc.rights.uri | 6 | - |
dc.subject | 8-Hydroxy-2-(di-n-propylamino)tetralin | - |
dc.subject | Animals | - |
dc.subject | Behavior, Animal | - |
dc.subject | Brain | - |
dc.subject | Compulsive Behavior | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Dopaminergic Neurons | - |
dc.subject | Drug Interactions | - |
dc.subject | Male | - |
dc.subject | Nerve Tissue Proteins | - |
dc.subject | Neurons | - |
dc.subject | Obsessive-Compulsive Disorder | - |
dc.subject | Quinpirole | - |
dc.subject | Random Allocation | - |
dc.subject | Rats | - |
dc.subject | Rats, Long-Evans | - |
dc.subject | Serotonergic Neurons | - |
dc.subject | Serotonin 5-HT1 Receptor Agonists | - |
dc.subject | Serotonin 5-HT2 Receptor Agonists | - |
dc.subject | Serotonin 5-HT3 Receptor Agonists | - |
dc.subject | Serotonin Receptor Agonists | - |
dc.subject | Spatial Behavior | - |
dc.title | Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit | - |
dc.type | Article | - |
dc.date.updated | 2021-08-10T19:32:15Z | - |
dc.contributor.department | Psychiatry & Behavioural Neurosciences | - |
dc.rights.license | Attribution-NonCommercial - CC BY-NC | - |
dc.identifier.doi | https://doi.org/10.1097/fbp.0b013e32835d5b7a | - |
Appears in Collections: | Psychiatry & Behavioural Neurosciences Publications |
Files in This Item:
File | Description | Size | Format | |
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Alkhatib_revised_2012-11-29.pdf | Submitted version | 766 kB | Adobe PDF | View/Open |
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