Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada

Sjaarda CP; Guthrie JL; Mubareka S; Simpson JT; Hamelin B; Wong H; Mortimer L; Slinger R; McArthur AG; Desjardins M; McGeer A; Mazzulli T; Douchant K; Brabant-Kirwan D; Fattouh R; Campigotto A; Patel SN; Fittipaldi N; Colautti RI; Sheth PM

Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/26587

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DC Field	Value	Language
dc.contributor.author	Sjaarda CP	-
dc.contributor.author	Guthrie JL	-
dc.contributor.author	Mubareka S	-
dc.contributor.author	Simpson JT	-
dc.contributor.author	Hamelin B	-
dc.contributor.author	Wong H	-
dc.contributor.author	Mortimer L	-
dc.contributor.author	Slinger R	-
dc.contributor.author	McArthur AG	-
dc.contributor.author	Desjardins M	-
dc.contributor.author	McGeer A	-
dc.contributor.author	Mazzulli T	-
dc.contributor.author	Douchant K	-
dc.contributor.author	Brabant-Kirwan D	-
dc.contributor.author	Fattouh R	-
dc.contributor.author	Campigotto A	-
dc.contributor.author	Patel SN	-
dc.contributor.author	Fittipaldi N	-
dc.contributor.author	Colautti RI	-
dc.contributor.author	Sheth PM	-
dc.date.accessioned	2021-06-15T15:39:04Z	-
dc.date.available	2021-06-15T15:39:04Z	-
dc.date.issued	2021-05-05	-
dc.identifier.issn	2379-5042	-
dc.identifier.issn	2379-5042	-
dc.identifier.uri	http://hdl.handle.net/11375/26587	-
dc.description.abstract	<jats:p>Genome-wide variation in SARS-CoV-2 reveals evolution and transmission dynamics which are critical considerations for disease control and prevention decisions. Here, we review estimates of the genome-wide viral mutation rates, summarize current COVID-19 case load in the province of Ontario, Canada (5 January 2021), and analyze published SARS-CoV-2 genomes from Ontario (collected prior to 24 November 2020) to test for more infectious genetic variants or lineages.</jats:p>	-
dc.publisher	American Society for Microbiology	-
dc.rights	Attribution - CC BY This Creative Commons license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. Recommended for maximum dissemination and use of licensed materials.	-
dc.rights.uri	2	-
dc.subject	COVID-19	-
dc.subject	G614D	-
dc.subject	PANGOLIN lineage	-
dc.subject	SARS-CoV-2	-
dc.subject	epidemiology	-
dc.subject	genetics	-
dc.subject	infectious disease	-
dc.subject	public health	-
dc.subject	Base Sequence	-
dc.subject	COVID-19	-
dc.subject	Genetic Variation	-
dc.subject	Genome, Viral	-
dc.subject	Humans	-
dc.subject	Mutation Rate	-
dc.subject	Ontario	-
dc.subject	Phylogeny	-
dc.subject	SARS-CoV-2	-
dc.subject	Sequence Analysis, RNA	-
dc.subject	Spike Glycoprotein, Coronavirus	-
dc.title	Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada	-
dc.type	Article	-
dc.date.updated	2021-06-15T15:39:03Z	-
dc.rights.license	Attribution - CC BY	-
dc.identifier.doi	https://doi.org/10.1128/msphere.00011-21	-
Appears in Collections:	Faculty Publications (via McMaster Experts)

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