Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/26158
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Duceppe E | - |
dc.contributor.author | Lauzon J | - |
dc.contributor.author | Galliger S | - |
dc.contributor.author | Zhang B | - |
dc.contributor.author | Solomon H | - |
dc.contributor.author | Serrano PE | - |
dc.date.accessioned | 2021-01-21T18:19:35Z | - |
dc.date.available | 2021-01-21T18:19:35Z | - |
dc.date.issued | 2020-11-29 | - |
dc.identifier.issn | 1538-7933 | - |
dc.identifier.issn | 1538-7836 | - |
dc.identifier.uri | http://hdl.handle.net/11375/26158 | - |
dc.description.abstract | BACKGROUND: Intraabdominal surgery is a known risk factor for splanchnic vein thrombosis (SVT). SVT incidence, management, and prognosis after hepatopancreatobiliary surgery are unknown. OBJECTIVES: To determine the incidence and prognosis of SVT following hepatopancreatobiliary surgery and describe current practices in anticoagulation for postoperative SVT. PATIENTS/METHODS: Multicenter retrospective cohort study of adults undergoing hepatopancreatobiliary surgery. Multivariable analyses for predictors of SVT, major bleeding, and 90-day mortality were performed. RESULTS: Of 1815 patients included, 89 (4.9%) had cirrhosis and 1532 (84.4%) had active cancer. The most frequent surgeries were pancreaticoduodenectomy (40.6%), open (30.7%), and laparoscopic (11.0%) liver resection. Sixty (3.3%) patients experienced SVT within 90 days of surgery. Among patients with SVT, 23.3% were symptomatic and 75.0% were treated with therapeutic anticoagulation. Planned duration of anticoagulation averaged 3 to 6 months. By multivariable analysis, SVT predictors were: operative time (adjusted odds ratio [aOR] per hour increase 1.32, 95% confidence interval [CI] 1.20-1.46), cirrhosis (aOR 3.22, 95% CI 1.28-8.10), and postoperative intraabdominal infection (aOR 2.99, 95% CI 1.72-5.19). Postoperative major bleeding occurred in 22.1% of patients and 4.0% died within 90 days. Predictors of postoperative mortality were age (aOR per 10-year increase 1.79, 95% CI 1.38-2.30), operative time (aOR 1.31 (1.17-1.45), cirrhosis (aOR 4.42, 95% CI 1.96-9.96), postoperative intraabdominal infection (aOR 2.66, 95% CI 1.55-4.57), postoperative major bleeding (aOR 4.12, 95% CI 2.36-7.30), and postoperative SVT (aOR 3.15, 95% CI 1.42-6.97). CONCLUSION: SVT occurred in 1 in 30 patients after hepatopancreatobiliary surgery and was associated with a 3-fold independent increase in 90-day mortality. | - |
dc.publisher | Wiley | - |
dc.subject | anticoagulants | - |
dc.subject | mortality | - |
dc.subject | observational study | - |
dc.subject | postoperative complications | - |
dc.subject | surgery | - |
dc.subject | venous thrombosis | - |
dc.title | Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery | - |
dc.type | Article | - |
dc.date.updated | 2021-01-21T18:19:35Z | - |
dc.contributor.department | Surgery | - |
dc.identifier.doi | 10.1111/jth.15198 | - |
Appears in Collections: | Surgery Publications |
Files in This Item:
There are no files associated with this item.
Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.