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http://hdl.handle.net/11375/23740
Title: | Evaluating the relationships between cardiovascular risk factors and carotid intima-media thickness over time in children and youth with obesity enrolled in a weight management program |
Other Titles: | Modifiable cardiovascular risk factors and carotid intima-media thickness in children and youth with obesity |
Authors: | Desai, Riddhi |
Advisor: | Morrison, Katherine |
Department: | Medical Sciences |
Publication Date: | 2018 |
Abstract: | INTRODUCTION: The high prevalence of obesity in Canadian children and youth predicts an increased burden of cardiometabolic disease across the life course. Carotid intima-media thickness (cIMT) is a surrogate marker of ATH and detects subclinical arterial wall abnormalities. However, relationships between modifiable cardiovascular risk factors (CVRFs) and cIMT progression in children and youth with obesity, remain understudied. PURPOSE: The study objective was to characterize cIMT progression and to identify CVRFs associated with baseline cIMT and change in cIMT, over time. HYPOTHESIS: It is hypothesized that measures of adiposity, BP, glycemia and lipid profile will be related to cIMT progression in children and youth with obesity and that cIMT progression will vary across carotid segments. METHODS: This longitudinal study included 125 children and youth with obesity (5-17y), enrolled in a Canadian Pediatric Weight Management Registry sub-study. B-mode ultrasonography was utilized to assess cIMT at baseline and 1-year follow-up. Measures of adiposity, BP, glycemia and lipid profile were acquired from clinical chart review. Potential relationships between CVRFs and cIMT progression were evaluated using univariable and multivariable regression. RESULTS: Carotid IMT (mm) changed significantly (p<0.001) at the carotid bulb, common carotid artery (CCA) and internal carotid artery (ICA), from baseline to 1-year, and cIMT progressed more rapidly than reported in children with diabetes/FH. Furthermore, cIMT progression was greatest at the carotid bulb, followed by the CCA and ICA. Baseline cIMT was positively related to SBP, TC/HDL-C, FPG and negatively related to HDL-C (corrected for age, sex, height). Change in cIMT at 1-year was positively related to BMI, non-HDL-C, TC/HDL-C and negatively related to HDL-C (corrected for age, sex, height, baseline cIMT). CONCLUSIONS: In children and youth with obesity, IMT progression was greater at the carotid bulb than at the CCA and ICA. Measures of adiposity, BP, glycemia and lipid profile were related to baseline cIMT and cIMT progression. |
URI: | http://hdl.handle.net/11375/23740 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Desai_Riddhi_FinalSubmission2018August_MSc.pdf | 3.58 MB | Adobe PDF | View/Open |
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