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http://hdl.handle.net/11375/23740
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DC Field | Value | Language |
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dc.contributor.advisor | Morrison, Katherine | - |
dc.contributor.author | Desai, Riddhi | - |
dc.date.accessioned | 2019-01-14T21:11:07Z | - |
dc.date.available | 2019-01-14T21:11:07Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://hdl.handle.net/11375/23740 | - |
dc.description.abstract | INTRODUCTION: The high prevalence of obesity in Canadian children and youth predicts an increased burden of cardiometabolic disease across the life course. Carotid intima-media thickness (cIMT) is a surrogate marker of ATH and detects subclinical arterial wall abnormalities. However, relationships between modifiable cardiovascular risk factors (CVRFs) and cIMT progression in children and youth with obesity, remain understudied. PURPOSE: The study objective was to characterize cIMT progression and to identify CVRFs associated with baseline cIMT and change in cIMT, over time. HYPOTHESIS: It is hypothesized that measures of adiposity, BP, glycemia and lipid profile will be related to cIMT progression in children and youth with obesity and that cIMT progression will vary across carotid segments. METHODS: This longitudinal study included 125 children and youth with obesity (5-17y), enrolled in a Canadian Pediatric Weight Management Registry sub-study. B-mode ultrasonography was utilized to assess cIMT at baseline and 1-year follow-up. Measures of adiposity, BP, glycemia and lipid profile were acquired from clinical chart review. Potential relationships between CVRFs and cIMT progression were evaluated using univariable and multivariable regression. RESULTS: Carotid IMT (mm) changed significantly (p<0.001) at the carotid bulb, common carotid artery (CCA) and internal carotid artery (ICA), from baseline to 1-year, and cIMT progressed more rapidly than reported in children with diabetes/FH. Furthermore, cIMT progression was greatest at the carotid bulb, followed by the CCA and ICA. Baseline cIMT was positively related to SBP, TC/HDL-C, FPG and negatively related to HDL-C (corrected for age, sex, height). Change in cIMT at 1-year was positively related to BMI, non-HDL-C, TC/HDL-C and negatively related to HDL-C (corrected for age, sex, height, baseline cIMT). CONCLUSIONS: In children and youth with obesity, IMT progression was greater at the carotid bulb than at the CCA and ICA. Measures of adiposity, BP, glycemia and lipid profile were related to baseline cIMT and cIMT progression. | en_US |
dc.language.iso | en | en_US |
dc.title | Evaluating the relationships between cardiovascular risk factors and carotid intima-media thickness over time in children and youth with obesity enrolled in a weight management program | en_US |
dc.title.alternative | Modifiable cardiovascular risk factors and carotid intima-media thickness in children and youth with obesity | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Medical Sciences | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
dc.description.layabstract | Approximately one third of Canadian children and youth have been classified as having overweight or obesity, and these individuals have an increased risk of developing cardiovascular disease and atherosclerosis, the narrowing of arteries, in adulthood. The measurement of intima and media layer thickness in the carotid artery wall (cIMT) is a dependable marker of atherosclerosis. However, relationships between cardiovascular risk factors and change in cIMT, over time, are not well studied in children and youth with obesity. This study evaluates relationships between change in cIMT, over time, and risk factors such as body composition, cholesterol, blood pressure and blood glucose in this population. Ultrasound scans were conducted to measure cIMT, and fasting blood samples were collected to detect cardiovascular risk factor levels. The findings of this study inform us on how cIMT progresses in children and youth with obesity and identify the factors that predict change in cIMT over time. | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Desai_Riddhi_FinalSubmission2018August_MSc.pdf | 3.58 MB | Adobe PDF | View/Open |
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