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http://hdl.handle.net/11375/21977Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Sheardown, Heather | - |
| dc.contributor.author | Muirhead, Ben | - |
| dc.date.accessioned | 2017-10-03T18:35:50Z | - |
| dc.date.available | 2017-10-03T18:35:50Z | - |
| dc.date.issued | 2017-11 | - |
| dc.identifier.uri | http://hdl.handle.net/11375/21977 | - |
| dc.description.abstract | This thesis will explore, both generally and very specifically, the role of biomaterials in drug delivery and tissue engineering applications. A novel therapeutic conjugate to treat dry eye disease using hyaluronic acid and sulfadiazine was created and tested using a benzalkonium chloride induced dry eye model. Thermoresponsive hydrogels based around poly(n-isopropylacrylamide) were synthesized to create a potential in situ gelling cell scaffold for cell delivery to the subretinal space. Finally, a mucoadhesive micelle was developed as a platform delivery system to increase bioavailability of drug in anterior segment therapeutics. | en_US |
| dc.language.iso | en | en_US |
| dc.subject | Biomaterials | en_US |
| dc.subject | Ophthalmology | en_US |
| dc.subject | cell delivery | en_US |
| dc.subject | cell scaffold | en_US |
| dc.subject | drug delivery | en_US |
| dc.subject | mucoadhesive | en_US |
| dc.title | Ophthalmic Biomaterials | en_US |
| dc.type | Thesis | en_US |
| dc.contributor.department | Biomedical Engineering | en_US |
| dc.description.degreetype | Thesis | en_US |
| dc.description.degree | Doctor of Philosophy (PhD) | en_US |
| Appears in Collections: | Open Access Dissertations and Theses | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Muirhead_Ben_B_201705_PhD_Biomedical Engineering.pdf | 3.95 MB | Adobe PDF | View/Open |
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