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http://hdl.handle.net/11375/19959
Title: | A Genetic Analysis of the Pyridoxine Auxotrophs of Neurospora crassa |
Authors: | Radford, Alan |
Advisor: | Threlkeld, S. F. H. |
Department: | Biology |
Keywords: | genetic analysis;pyrodoxine auxotrophs;Neurospora crassa;biology |
Publication Date: | Aug-1966 |
Abstract: | <p> Evidence of gene conversion and inter=allelic complementation from earlier work on the pdx-1 locus of Neurospora crassa suggested that a more detailed analysis of this locus should lead to a better understanding of these genetic phenomenao The work described in this thesis is concerned with the derivation of complementation maps for seven alleles of the pdx-1 locus, and with a study of recombination between these alleles through the isolation of prototrophs from suitably marked inter-allelic crosses together with the isolation of asci including those exhibiting the phenomenon of gene conversione In additioni the relationships betwean the pdx-1 alleles and a gene, en-pdx-1, affecting the excretion of a pigment into the medium on which the pdx-1 strains were grown were studied. The effect of desoxypyridoxine hydrochloride 9 and the extent to which the pdx-1 mutants respond to various normal forms of the vitamin, were also studied. </p> |
URI: | http://hdl.handle.net/11375/19959 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Radford_Alan_1966Aug_phd.pdf | 6.25 MB | Adobe PDF | View/Open |
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