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http://hdl.handle.net/11375/18558
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DC Field | Value | Language |
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dc.contributor.advisor | Bell, R. A. | - |
dc.contributor.author | Gravestock, Michael Barry | - |
dc.date.accessioned | 2015-11-11T14:55:30Z | - |
dc.date.available | 2015-11-11T14:55:30Z | - |
dc.date.issued | 1969-09 | - |
dc.identifier.uri | http://hdl.handle.net/11375/18558 | - |
dc.description.abstract | <p> The previously known, 8-oxo-(13→17)-pentanorlabda-12,19-dioic acid 19-methyl ester 36, was synthesised via two routes following the extensive investigation of the dehydrobromination of bromo-ketone 48, and also partial ozonolysis of the phenolic ring of podocarpic acid. </p> <p> This keto-acid 36 has been transformed to the corresponding 8-methylene compound in high yield. Application of the latter intermediate to diterpene synthesis has been demonstrated by the synthesis of 12-hydroxylabd-8(17)-en-19-oic acid 37 and methyl 12-ketolambertianate 61. </p> <p> During investigation of other synthetic intermediates a selective reducing agent for carboxylic esters in the presence of the carboxylic acid function - sodium trimethoxyborohydride, has been discovered. </p> | en_US |
dc.language.iso | en | en_US |
dc.subject | chemistry | en_US |
dc.subject | synthesis | en_US |
dc.subject | labdane diterpenoid | en_US |
dc.title | Synthesis of Labdane Diterpenoids | en_US |
dc.contributor.department | Chemistry | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Doctor of Philosophy (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Gravestock_Michael_B_1969Sept_PhD.pdf | 50.25 MB | Adobe PDF | View/Open |
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