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http://hdl.handle.net/11375/17921
Title: | The Distribution of Manganese in Blood |
Authors: | Hancock, Ronald George Vincent |
Advisor: | Fritze, K. |
Department: | Chemistry |
Keywords: | manganese, blood serum, erythrocytes, radioactive tracer method, gel chromatography, disc gel electrophoresis, labile manganese complex, vitro, in vivo |
Publication Date: | Sep-1970 |
Abstract: | <p> The distribution of manganese in blood serum and erythrocytes has been investigated using a combination of radioactive tracer method with both gel chromatography and disc gel electrophoresis. </p> <p> In serum, there are two manganese-binding proteins. The first is a(beta)1 globulin with a molecular weight of 70,000. This forms a relatively labile manganese complex both in vitro and in vivo, and is remarkably similar in both its chromatographic and electrophoretic behaviour to the iron-binding protein, transferrin. The second protein is a higher molecular weight (beta) globulin. It is found to incorporate radiomanganese in vivo only, thereupon forming a very stable entity. </p> <p> In erythrocytes, manganese occurs predominantly in a porphyrin bound to apoglobin, giving rise to a species similar to hemoglobin . </p> |
URI: | http://hdl.handle.net/11375/17921 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Hancock_Ronald_G.V._Sept1970_PhD.pdf | 43.42 MB | Adobe PDF | View/Open |
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