The Distribution of Manganese in Blood

Hancock, Ronald George Vincent

Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/17921

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DC Field	Value	Language
dc.contributor.advisor	Fritze, K.	-
dc.contributor.author	Hancock, Ronald George Vincent	-
dc.date.accessioned	2015-08-19T14:08:58Z	-
dc.date.available	2015-08-19T14:08:58Z	-
dc.date.issued	1970-09	-
dc.identifier.uri	http://hdl.handle.net/11375/17921	-
dc.description.abstract	<p> The distribution of manganese in blood serum and erythrocytes has been investigated using a combination of radioactive tracer method with both gel chromatography and disc gel electrophoresis. </p> <p> In serum, there are two manganese-binding proteins. The first is a(beta)1 globulin with a molecular weight of 70,000. This forms a relatively labile manganese complex both in vitro and in vivo, and is remarkably similar in both its chromatographic and electrophoretic behaviour to the iron-binding protein, transferrin. The second protein is a higher molecular weight (beta) globulin. It is found to incorporate radiomanganese in vivo only, thereupon forming a very stable entity. </p> <p> In erythrocytes, manganese occurs predominantly in a porphyrin bound to apoglobin, giving rise to a species similar to hemoglobin . </p>	en_US
dc.language.iso	en	en_US
dc.subject	manganese, blood serum, erythrocytes, radioactive tracer method, gel chromatography, disc gel electrophoresis, labile manganese complex, vitro, in vivo	en_US
dc.title	The Distribution of Manganese in Blood	en_US
dc.type	Thesis	en_US
dc.contributor.department	Chemistry	en_US
dc.description.degreetype	Thesis	en_US
dc.description.degree	Doctor of Philosophy (PhD)	en_US
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