Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/17744
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Freeman, K. B. | - |
dc.contributor.author | Fettes, Ivy Marlys | - |
dc.date.accessioned | 2015-07-15T15:12:28Z | - |
dc.date.available | 2015-07-15T15:12:28Z | - |
dc.date.issued | 1970-08 | - |
dc.identifier.uri | http://hdl.handle.net/11375/17744 | - |
dc.description.abstract | Chloramphenicol has been used to study mitochondrial biogenesis in mammalian cells by examining its effect on: the incorporation of radioactive amino acids into protein by isolated mitochondria, the growth of L cells, the level of representative enzymes and cytochromes in the mitochondria and cytoplasm and the structure of mitochondria and L cells. A reversible inhibition of synthesis of cytochrome c oxidase was obtained by treating cells with D-threo-chloramphenicol for 90 hr. Recovery of cytochrome c oxidase activity was inhibited by cycloheximide, an inhibitor of cytoplasmic protein synthesis. Cycloheximide also reversibly inhibited cytochrome c oxidase formation in cells which were not treated with D-chloramphenicol. It is suggested that the mitochondria and the nucleus have a joint control in the formation of a functionally active cytochrome c oxidase enzyme. | en_US |
dc.language.iso | en | en_US |
dc.subject | biochemistry, biophysics, molecular biology | en_US |
dc.subject | biogenesis | en_US |
dc.subject | mitochondria | en_US |
dc.subject | mammalian cell | en_US |
dc.subject | L cell | en_US |
dc.title | The Biogenesis of Mitochondria in Mammalian Cells (L Cells) | en_US |
dc.contributor.department | Biochemistry | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Doctor of Philosophy (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fettes_Ivy_M_1970Aug_PhD.pdf | 26.92 MB | Adobe PDF | View/Open |
Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.