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http://hdl.handle.net/11375/13496
Title: | CLINICAL SEVERITY OF RHINOVIRUS/ENTEROVIRUS COMPARED TO OTHER RESPIRATORY VIRUSES IN CHILDREN |
Authors: | Asner, Andrea Sandra |
Advisor: | Smieja, Marek Mertz, Dominik Hamid, Jemila |
Department: | Clinical Epidemiology/Clinical Epidemiology & Biostatistics |
Keywords: | Human rhinovirus/enterovirus (HRV/ENT);respiratory syncytial virus (RSV);influenza (FLU);single viral infections;clinical disease severity;acute respiratory infections;upper respiratory tract infections;lower respiratory tract infections;community-acquired pneumonia;molecular assays;Infectious Disease;Medicine and Health Sciences;Pediatrics;Infectious Disease |
Publication Date: | Oct-2013 |
Abstract: | <p><strong>Background</strong>: Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remains limited. We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU) and other common respiratory virus in children.</p> <p><strong>Methods</strong>: Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite end-point consisting of intensive care admission, hospitalization greater than 5 days, oxygen requirements or death.</p> <p><strong>Results</strong>: A total of 116 HRV/ENT, 102 RSV, 99 FLU and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37.9% vs 13.6%; p</p> <p><strong>Conclusions</strong>: Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections.</p> |
URI: | http://hdl.handle.net/11375/13496 |
Identifier: | opendissertations/8328 9168 4526155 |
Appears in Collections: | Open Access Dissertations and Theses |
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