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http://hdl.handle.net/11375/13496
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DC Field | Value | Language |
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dc.contributor.advisor | Smieja, Marek | en_US |
dc.contributor.advisor | Mertz, Dominik | en_US |
dc.contributor.advisor | Hamid, Jemila | en_US |
dc.contributor.author | Asner, Andrea Sandra | en_US |
dc.date.accessioned | 2014-06-18T17:04:13Z | - |
dc.date.available | 2014-06-18T17:04:13Z | - |
dc.date.created | 2013-08-29 | en_US |
dc.date.issued | 2013-10 | en_US |
dc.identifier.other | opendissertations/8328 | en_US |
dc.identifier.other | 9168 | en_US |
dc.identifier.other | 4526155 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/13496 | - |
dc.description.abstract | <p><strong>Background</strong>: Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remains limited. We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU) and other common respiratory virus in children.</p> <p><strong>Methods</strong>: Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite end-point consisting of intensive care admission, hospitalization greater than 5 days, oxygen requirements or death.</p> <p><strong>Results</strong>: A total of 116 HRV/ENT, 102 RSV, 99 FLU and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37.9% vs 13.6%; p</p> <p><strong>Conclusions</strong>: Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections.</p> | en_US |
dc.subject | Human rhinovirus/enterovirus (HRV/ENT) | en_US |
dc.subject | respiratory syncytial virus (RSV) | en_US |
dc.subject | influenza (FLU) | en_US |
dc.subject | single viral infections | en_US |
dc.subject | clinical disease severity | en_US |
dc.subject | acute respiratory infections | en_US |
dc.subject | upper respiratory tract infections | en_US |
dc.subject | lower respiratory tract infections | en_US |
dc.subject | community-acquired pneumonia | en_US |
dc.subject | molecular assays | en_US |
dc.subject | Infectious Disease | en_US |
dc.subject | Medicine and Health Sciences | en_US |
dc.subject | Pediatrics | en_US |
dc.subject | Infectious Disease | en_US |
dc.title | CLINICAL SEVERITY OF RHINOVIRUS/ENTEROVIRUS COMPARED TO OTHER RESPIRATORY VIRUSES IN CHILDREN | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Clinical Epidemiology/Clinical Epidemiology & Biostatistics | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
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fulltext.pdf | 613.47 kB | Adobe PDF | View/Open |
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