Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/11167
Title: | EFFECT OF SMOKING AND CESSATION IN HIV-INFECTED PEOPLE |
Authors: | Cui, Qu |
Advisor: | Smieja, Marek Jozef Thabane, Lehana Andrew McIvor, Fiona Smaill |
Department: | Health Research Methodology |
Keywords: | HIV;smoking;smoking cessation;multiple imputation;varenicline;Canada;Clinical Epidemiology;Clinical Epidemiology |
Publication Date: | Oct-2011 |
Abstract: | <p>Cigarette smoking is prevalent in HIV-infected people, resulting in higher mortality rate and more premature heart and lung diseases in the highly active antiretroviral therapy era. Smoking is a modifiable risk factor for these adverse outcomes and smoking cessation in HIV-positive smokers is feasible, although further efforts are needed to improve smoking cessation programs in HIV-positive persons.</p> <p>In this thesis, I examined the role of smoking in mortality and morbidity in HIV-positive Ontarians, and piloted a smoking cessation program featuring a novel smoking cessation aid, varenicline, in HIV-infected smokers. In addition, I explored three different methods to resolve missing data, by excluding, grouping and multiply imputing missing data. I adopted three different study designs in my thesis studies: retrospective cohort, cross-sectional and open label study.</p> <p>We found smoking prevalence in HIV-infected people was consistently higher than in the general population. Smoking was associated with a higher risk of death, of respiratory symptoms, hospitalization and chronic obstructive pulmonary disease, and with reduced lung function and less CD4-T-lymphocyte improvement over time. We found varenicline was as effective in HIV-positive smokers as in non-HIV smokers reported by previous studies.</p> |
URI: | http://hdl.handle.net/11375/11167 |
Identifier: | opendissertations/6156 7161 2231208 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
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fulltext.pdf | 706.83 kB | Adobe PDF | View/Open |
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