Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/10561
Title: | Biosynthesis of Lycopodium Alkaloids |
Authors: | Marshall, William D. |
Advisor: | MacLean, D.B. |
Department: | Chemistry |
Keywords: | Chemistry;Chemistry |
Publication Date: | Aug-1973 |
Abstract: | <p>An investigation of the biosynthesis of lycopodine, the major alkaloid of Lycopodium tristachyum, has revealed that L-lysine, but not D-lysine is incorporated into this alkaloid. D-lysine serves as a precursor to pipecolic acid in this species. Sodium malonate has been demonstrated to be a specific precursor to lycopodine, but attempts to verify the postulated intermediacy of piperidineacetic acid. In the elaboration of this alkaloid were unsuccessful.</p> <p>As a means of studying the postulated conversion of lycopodine to annotinine, the major alkaloid of Lycopodium annotinum, specifically labelled 9-14C-lycopodine was synthesized. However the specific incorporation into annotinine of several precursors known to be incorporated into lycopodine could not be demonstrated.</p> |
URI: | http://hdl.handle.net/11375/10561 |
Identifier: | opendissertations/56 1559 924746 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 4.57 MB | Adobe PDF | View/Open |
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