Biosynthesis of Lycopodium Alkaloids

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DC Field	Value	Language
dc.contributor.advisor	MacLean, D.B.	en_US
dc.contributor.author	Marshall, William D.	en_US
dc.date.accessioned	2014-06-18T16:51:52Z	-
dc.date.available	2014-06-18T16:51:52Z	-
dc.date.created	2009-08-05	en_US
dc.date.issued	1973-08	en_US
dc.identifier.other	opendissertations/56	en_US
dc.identifier.other	1559	en_US
dc.identifier.other	924746	en_US
dc.identifier.uri	http://hdl.handle.net/11375/10561	-
dc.description.abstract	<p>An investigation of the biosynthesis of lycopodine, the major alkaloid of Lycopodium tristachyum, has revealed that L-lysine, but not D-lysine is incorporated into this alkaloid. D-lysine serves as a precursor to pipecolic acid in this species. Sodium malonate has been demonstrated to be a specific precursor to lycopodine, but attempts to verify the postulated intermediacy of piperidineacetic acid. In the elaboration of this alkaloid were unsuccessful.</p> <p>As a means of studying the postulated conversion of lycopodine to annotinine, the major alkaloid of Lycopodium annotinum, specifically labelled 9-14C-lycopodine was synthesized. However the specific incorporation into annotinine of several precursors known to be incorporated into lycopodine could not be demonstrated.</p>	en_US
dc.subject	Chemistry	en_US
dc.subject	Chemistry	en_US
dc.title	Biosynthesis of Lycopodium Alkaloids	en_US
dc.type	thesis	en_US
dc.contributor.department	Chemistry	en_US
dc.description.degree	Doctor of Philosophy (PhD)	en_US
Appears in Collections:	Open Access Dissertations and Theses

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