The Mode of Action of Nitrofurazone on Bacteria

dc.contributor.advisor	McCalla, D.R.	en_US
dc.contributor.author	Tu, Yu	en_US
dc.contributor.department	Biology	en_US
dc.date.accessioned	2014-06-18T17:03:54Z
dc.date.available	2014-06-18T17:03:54Z
dc.date.created	2009-08-25	en_US
dc.date.issued	1975-12	en_US
dc.description.abstract	<p>Studies are described which show that activated nitrofurazone is able to cause damage to covalently closed circular DNA in minicells from Escherichia coli strain x 1256. These results are discussed in terms of the nature of the damage and of the repair of this damage in minicells.</p> <p>Studies on the effect of nitrofurazone on macromolecules in Escherichia coli B/r have shown that the activated nitrofurazone inhibits the synthesis of RNA and ribosomes and causes damage to the function of ribosomes. Studies have also shown that the activated nitrofurazone inhibits aerobic and anaerobic metabolism and lowers the ATP levels in bacteria. The mechanism by which these effects are produced are discussed.</p>	en_US
dc.description.degree	Doctor of Philosophy (PhD)	en_US
dc.identifier.other	opendissertations/825	en_US
dc.identifier.other	1773	en_US
dc.identifier.other	969780	en_US
dc.identifier.uri	http://hdl.handle.net/11375/13429
dc.subject	Biology	en_US
dc.subject	Biology	en_US
dc.title	The Mode of Action of Nitrofurazone on Bacteria	en_US
dc.type	thesis	en_US

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