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The Effects of Infection with Adenoviruses on the Chromosomes of Human Cells and Syrian Hamster Cells

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dc.contributor.advisorStich, H. F.
dc.contributor.authorCooper, John Ernest Keith
dc.contributor.departmentBiologyen_US
dc.date.accessioned2015-06-15T22:39:39Z
dc.date.available2015-06-15T22:39:39Z
dc.date.issued1968-10
dc.description.abstractNo abstract provided.en_US
dc.description.degreeDoctor of Philosophy (PhD)en_US
dc.description.degreetypeThesisen_US
dc.description.layabstractScope and contents: Seven adenoviruses, including oncogenic and nononcogenic serotypes from human and simian hosts, were utilized to investigate their effects upon the chromosomes of human and Syrian hamster cells. Human cells support adenovirus multiplication while hamster cells do not support replication of infectious adenovirus. The chromosome damage induced by adenoviruses in abortive infection of hamster cells was compared with respect to the effect of virus dose upon the incidence and the types of chromosome aberrations. The effect of different adenoviruses upon the amount and types of chromosome damage was also examined. The effect of adenovirus infection upon DNA synthesis of human and hamster cells was examined, and the relevance of adenovirus-induced chromosome aberrations to the etiology of human cancers is discussed.en_US
dc.identifier.urihttp://hdl.handle.net/11375/17554
dc.language.isoenen_US
dc.subjectadenovirusen_US
dc.subjectoncogenicen_US
dc.subjectnon-oncogenicen_US
dc.subjecthuman cellsen_US
dc.subjectSyrian hamster cellsen_US
dc.subjectchromosome damageen_US
dc.subjectreplicationen_US
dc.titleThe Effects of Infection with Adenoviruses on the Chromosomes of Human Cells and Syrian Hamster Cellsen_US
dc.typeThesisen_US

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