Temperature-Dependent Dielectric Properties of Tissue Phantoms and Tissue Samples at Microwave Frequencies

Abstract

<p>Accurate knowledge of the frequency- and temperature-dependent dielectric properties of biological tissues is crucial in the development of ultra-wideband diagnostic and therapeutic technologies such as microwave breast cancer detection and hyperthermia treatments. This work examines the temperature dependence of the dielectric properties of the five tissue phantom-types developed by our group as well as porcine fat, muscle and liver tissues for the frequency range from 3 GHz to 10 GHz and for the temperature range from 5 °C to 45 °C. A systematic and simple measurement procedure is developed to measure the continuous temperature dependence of the dielectric properties of the various phantom and tissue types. The temperature trends of the dielectric properties of the different phantoms and tissues are investigated.</p> <p>Linear temperature coefficients at discrete frequencies are impractical and insufficient in ultra-wideband applications when realistic, non-linear numerical models of the dielectric properties are required. Therefore, a compact one-pole Cole-Cole model is used to model the frequency dependence of the dielectric properties of the measured samples at every temperature point. A second- or third-order polynomial is used to model the temperature dependence of the Cole-Cole parameters. The final model is a one-pole Cole-Cole model whose parameters are polynomial functions of temperature. This model enables the estimation of the relative permittivity and the conductivity of the measured phantom and tissue types at any temperature and frequency.</p>