The Synthesis and Characterization of Some N-Hydroxyaminopyrenes
| dc.contributor.advisor | McCarry, B. E. | |
| dc.contributor.author | Mills, William James | |
| dc.contributor.department | Chemistry | en_US |
| dc.date.accessioned | 2022-06-27T15:49:18Z | |
| dc.date.available | 2022-06-27T15:49:18Z | |
| dc.date.issued | 1990-10 | |
| dc.description.abstract | Nitrated polycyclic aromatic hydrocarbons (nitro-PAH) are environmental contaminants that have been identified in extracts of particulates obtained from automobile exhaust, diesel exhaust, and power plant emissions. One of the most abundant nitro-PAH, 1-nitropyrene, has been found to be a powerful bacterial mutagen and a carcinogen in animal tests. In a bacterial strain (Salmonella tvphimurium TA98) 1- nitropyrene undergoes reduction and concomitant covalent binding to DNA, presumably via the N-hydroxy-l-aminopyrene. This labile compound was prepared by the ascorbic acid reduction of 1-nitrosopyrene and was characterized by high performance liquid chromatography (HPLC), combined liquid chromatography-mass spectrometry (LC-MS), ultraviolet-visible (UV-VIS), fluorescence and nuclear magnetic resonance (NMR) spectroscopy (1H and 15N) . In addition the pH stability and some reactions of this compound were studied. The 1,6- and 1,8-hydroxylaminonitropyrenes derived from the very potent mutagens 1,6- and 1,8 dinitropyrene were also synthesized and characterized by high performance liquid chromatography, ultraviolet-visible and nuclear magnetic resonance spectroscopy (1H and 15N) . | en_US |
| dc.description.degree | Master of Science (MSc) | en_US |
| dc.description.degreetype | Thesis | en_US |
| dc.identifier.uri | http://hdl.handle.net/11375/27672 | |
| dc.language.iso | en | en_US |
| dc.subject | N-Hydroxyaminopyrenes, synthesis, nitropyrene, nitro-PAH, dinitropyrenes | en_US |
| dc.title | The Synthesis and Characterization of Some N-Hydroxyaminopyrenes | en_US |
| dc.title.alternative | N-Hydroxyaminopyrenes | en_US |
| dc.type | Thesis | en_US |