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http://hdl.handle.net/11375/9281
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DC Field | Value | Language |
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dc.contributor.advisor | Xu, Jianping | en_US |
dc.contributor.author | Shahid, Morvarid | en_US |
dc.date.accessioned | 2014-06-18T16:46:28Z | - |
dc.date.available | 2014-06-18T16:46:28Z | - |
dc.date.created | 2011-06-02 | en_US |
dc.date.issued | 2006-06 | en_US |
dc.identifier.other | opendissertations/4418 | en_US |
dc.identifier.other | 5438 | en_US |
dc.identifier.other | 2042942 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/9281 | - |
dc.description.abstract | <p>Recent population genetic studies have revealed that there are multiple natural hybridizations among divergent lineages in the human pathogenic fungus <em>Cryptococcus neoformans</em>. However, the biological and phenotypic effects of such hybridization are little understood. In this study, we constructed a laboratory cross between two genetically diverged strains; chosen because they differed in growth at different temperature and medium conditions and in their susceptibilities to the common antifungal drug Fluconazole. Our analyses indicated evidence of environment-specific outbreeding depression and intermediate phenotypes in the hybrid population of <em>C. neoformans</em>. A variable number of progeny displayed evidence of transgressive segregation. With increasing drug concentration, the relative fitness of transgressive hybrids also increased. The analyses showed that the progeny population had a greater phenotypic plasticity than the parental strains. Our study suggested that hybridization can playa significant role in the evolution of this important human pathogenic fungus.</p> | en_US |
dc.title | THE EFFECT OF ENVIRONMETAL FACTORS ON HYBRID FITNESS IN CRYPTOCOCCUS NEOFORMUNS | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Biology | en_US |
dc.description.degree | Master of Science (MS) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 3.94 MB | Adobe PDF | View/Open |
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