Chromatin RNA Components

Monahan, John J.

Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/7713

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DC Field	Value	Language
dc.contributor.advisor	Hall, Ross H.	en_US
dc.contributor.author	Monahan, John J.	en_US
dc.date.accessioned	2014-06-18T16:40:14Z	-
dc.date.available	2014-06-18T16:40:14Z	-
dc.date.created	2010-08-03	en_US
dc.date.issued	1973-04	en_US
dc.identifier.other	opendissertations/2971	en_US
dc.identifier.other	3979	en_US
dc.identifier.other	1422748	en_US
dc.identifier.uri	http://hdl.handle.net/11375/7713	-
dc.description.abstract	<p>Almost all the genetic information of the eucaryotic cell is contained in the nuclear chromosomes. How regulation of the expression of this information takes place still remains as one of the great mysteries of the Biological Sciences. In this thesis an attempt is made to look at a few of the chemical components that may be involved in this process.</p> <p>Chromatin (the interphase form of the eucaryotic cell genome) of a number of tissue culture cell lines has been fractionated using some novel techniques into its four major components: DNA, RNA, histones and non-histone proteins.</p> <p>Of these four fractions the RNA fraction has remained the least well characterized. This thesis attempts to demonstrate that the RNA fraction in chromatin, in contrary to the opinion of a number of people at present, a complex fraction, quite distinct from other cellular RNA components. A model is presented whereby gene regulation in eycaryotic cells takes place via the interaction of chromosomal protein and RNA components.</p>	en_US
dc.subject	Biochemistry	en_US
dc.subject	Biochemistry	en_US
dc.title	Chromatin RNA Components	en_US
dc.type	thesis	en_US
dc.contributor.department	Biochemistry	en_US
dc.description.degree	Doctor of Philosophy (PhD)	en_US
Appears in Collections:	Open Access Dissertations and Theses

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