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http://hdl.handle.net/11375/7480
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DC Field | Value | Language |
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dc.contributor.advisor | Nelson, Harvey Lauris | en_US |
dc.contributor.author | Nelson, Lauris Harvey | en_US |
dc.date.accessioned | 2014-06-18T16:39:29Z | - |
dc.date.available | 2014-06-18T16:39:29Z | - |
dc.date.created | 2010-07-26 | en_US |
dc.date.issued | 1979-09 | en_US |
dc.identifier.other | opendissertations/2756 | en_US |
dc.identifier.other | 3820 | en_US |
dc.identifier.other | 1409646 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/7480 | - |
dc.description.abstract | <p>The purpose of this thesis is to describe a research strategy for evaluating the efficacy of a reduced dose maternal tetanus immunization schedule in reducing neonatal tetanus deaths in Sierra Leone.</p> <p>Neonatal tetanus has been demonstrated to be a major cause in infant death in areas where sanitary midwifery is unavailable. A review of the literature reveals evidence for reduction in neonatal tetanus deaths by maternal immunization using a conventional three dose adsorbed tetanus toxoid.</p> <p>In Sierra Leone, as in many developing countries, the resources are unavailable to maintain a three-dose schedule in the relatively inaccessible interior of the country. A two-dose schedule of a concentrated adsorbed toxoid has been recommended as an alternative by the World Health Organization. Research on simplified immunization schedules has been reviewed; the results are inconclusive.</p> <p>A double-blind randomized placebo-controlled design has been selected to address the research questions. Various aspects of this design are discussed with respect to methodologic and ethical issues.</p> <p>Procedures for carrying out the trial and for the assessment of neonatal tetanus death in a remote chiefdom in Sierra Leone are proposed. A procedure for the analysis of outcome data is presented.</p> | en_US |
dc.subject | Health Services Research | en_US |
dc.subject | Health Services Research | en_US |
dc.title | A Randomized Controlled Field Trial of the Efficacy of a Simplified Maternal Immunization Schedule in Reducing Neonatal Tetanus Deaths in Rural Sierra Leone | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Design, Measurement and Evaluation: Health Care Research Methods | en_US |
dc.description.degree | Master of Science (MS) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 5.87 MB | Adobe PDF | View/Open |
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