A Method for the Determination of Non-ceruloplasmin-bound Copper in Blood Serum and Some of Its Applications

Tam, Kwai-Hong

Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/5679

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DC Field	Value	Language
dc.contributor.advisor	Fritze, K.	en_US
dc.contributor.author	Tam, Kwai-Hong	en_US
dc.date.accessioned	2014-06-18T16:32:37Z	-
dc.date.available	2014-06-18T16:32:37Z	-
dc.date.created	2009-08-06	en_US
dc.date.issued	1973-08	en_US
dc.identifier.other	opendissertations/1025	en_US
dc.identifier.other	1573	en_US
dc.identifier.other	926776	en_US
dc.identifier.uri	http://hdl.handle.net/11375/5679	-
dc.description.abstract	<p>Methods have been developed to analyse for the non ceruloplasmin-bound copper and total copper in human blood serum accurately and precisely. The former was firstly isolated from the serum by using Chelex 100 resin. Both the non-ceruloplasmin-bound copper and the total copper were determined by neturon activation analysis, atomic absorption spectroscopy and a spectrophotometric method using zinc dibenzyldithiocarbamate as the chelating agent. Then the concentration of the ceruloplasmin-bound copper could be calculated by the difference. In vitro and in vivo radioisotopic labelling techniques were used in establishing the methods. Then they were applied to analyse the blood sera from some Caucasians, Chinese and a person with glomerulonephritis. The variations of the copper concentration as a function of time of one Chinese volunteer were also studied.</p>	en_US
dc.subject	Chemistry	en_US
dc.subject	Chemistry	en_US
dc.title	A Method for the Determination of Non-ceruloplasmin-bound Copper in Blood Serum and Some of Its Applications	en_US
dc.type	thesis	en_US
dc.contributor.department	Chemistry	en_US
dc.description.degree	Doctor of Philosophy (PhD)	en_US
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