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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/30593
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dc.contributor.authorDave, Ridhdhi-
dc.contributor.authorMofford, Jon-
dc.contributor.authorHicks, Emily Anne-
dc.contributor.authorSingh, Andrew-
dc.contributor.authorSheardown, Heather-
dc.contributor.authorHoare, Todd-
dc.date.accessioned2024-11-25T13:46:24Z-
dc.date.available2024-11-25T13:46:24Z-
dc.date.issued2024-11-22-
dc.identifier.citationhttps://doi.org/10.1039/D4NR03805Cen_US
dc.identifier.urihttp://hdl.handle.net/11375/30593-
dc.description.abstractThe capacity to tune the degree of mucoadhesion and mucopenetration of nanoparticles is essential to improving drug bioavailability, transport, and efficacy at mucosal interfaces. Herein, self-assembled nanoparticles (NPs) fabricated from amphiphilic block copolymers of poly(lactic acid) (PLA) and poly(oligo(ethylene glycol) methacrylate) (POEGMA) with various side chain lengths (PLA-POEGMAn) are reported to facilitate tunable mucosal interactions. PLA-POEGMAn nanoparticles with long PEG side chain lengths (n=20, or 40) demonstrated mucoadhesive properties based on rheological synergism, calorimetric tracking of mucin-nanoparticle interactions, and the formation of larger NP-mucin hybrid structures; in contrast, NPs fabricated from block copolymers with shorter PEG side chains (n=2/8-9 or n=8,9) showed poor mucoadhesion but penetrated through the mucin layer with significantly higher permeation rates (>80%). All NP formulations showed good cytocompatibility (viability >70%) with human corneal epithelial cells in vitro and no detectable acute in vivo ocular irritation in Sprague-Dawley rats. Coupled with the capacity of the synthetic route to easily incorporate different brush lengths and/or different functional groups into the hydrophilic block, we anticipate this approach may offer a solution in applications in which balancing mucoadhesion and mucopenetration is critical for enabling effective drug delivery.en_US
dc.description.sponsorshipThe authors would like to thank Paul Gatt and Justin Bernar for the construction of the CIJ-M device. Financial support the Natural Sciences and Engineering Research Council of Canada (NSERC – Discovery Grant RGPIN-2017-06455 to TH), the NSERC CREATE Training Program for Controlled Release Leaders (ContRoL), the Ontario Research Fund (grant #RE11-049 to HS) and the Canada Research Chairs program (CRC-2020-00135 to TH) is gratefully acknowledged.en_US
dc.language.isoenen_US
dc.publisherNanoscaleen_US
dc.titleTuning mucoadhesion and mucopenetration in self-assembled poly(lactic acid)-block-poly(oligoethylene glycol methacrylate) block copolymer nanoparticles by controlling side-chain lengthsen_US
dc.typeArticleen_US
dc.contributor.departmentChemical Engineeringen_US
Appears in Collections:Student Publications (Not Graduate Theses)

Files in This Item:
File Description SizeFormat 
PLA-POEMGA_mucoadhesive_mucopenetrative_paper_RD_TH_Edit_Vf1.pdf
Open Access
Manuscript1.46 MBAdobe PDFView/Open
Supporting Information PLA-POEGMA Paper_final.pdf
Open Access
Supporting Information1.63 MBAdobe PDFView/Open
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