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http://hdl.handle.net/11375/30593
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DC Field | Value | Language |
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dc.contributor.author | Dave, Ridhdhi | - |
dc.contributor.author | Mofford, Jon | - |
dc.contributor.author | Hicks, Emily Anne | - |
dc.contributor.author | Singh, Andrew | - |
dc.contributor.author | Sheardown, Heather | - |
dc.contributor.author | Hoare, Todd | - |
dc.date.accessioned | 2024-11-25T13:46:24Z | - |
dc.date.available | 2024-11-25T13:46:24Z | - |
dc.date.issued | 2024-11-22 | - |
dc.identifier.citation | https://doi.org/10.1039/D4NR03805C | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/30593 | - |
dc.description.abstract | The capacity to tune the degree of mucoadhesion and mucopenetration of nanoparticles is essential to improving drug bioavailability, transport, and efficacy at mucosal interfaces. Herein, self-assembled nanoparticles (NPs) fabricated from amphiphilic block copolymers of poly(lactic acid) (PLA) and poly(oligo(ethylene glycol) methacrylate) (POEGMA) with various side chain lengths (PLA-POEGMAn) are reported to facilitate tunable mucosal interactions. PLA-POEGMAn nanoparticles with long PEG side chain lengths (n=20, or 40) demonstrated mucoadhesive properties based on rheological synergism, calorimetric tracking of mucin-nanoparticle interactions, and the formation of larger NP-mucin hybrid structures; in contrast, NPs fabricated from block copolymers with shorter PEG side chains (n=2/8-9 or n=8,9) showed poor mucoadhesion but penetrated through the mucin layer with significantly higher permeation rates (>80%). All NP formulations showed good cytocompatibility (viability >70%) with human corneal epithelial cells in vitro and no detectable acute in vivo ocular irritation in Sprague-Dawley rats. Coupled with the capacity of the synthetic route to easily incorporate different brush lengths and/or different functional groups into the hydrophilic block, we anticipate this approach may offer a solution in applications in which balancing mucoadhesion and mucopenetration is critical for enabling effective drug delivery. | en_US |
dc.description.sponsorship | The authors would like to thank Paul Gatt and Justin Bernar for the construction of the CIJ-M device. Financial support the Natural Sciences and Engineering Research Council of Canada (NSERC – Discovery Grant RGPIN-2017-06455 to TH), the NSERC CREATE Training Program for Controlled Release Leaders (ContRoL), the Ontario Research Fund (grant #RE11-049 to HS) and the Canada Research Chairs program (CRC-2020-00135 to TH) is gratefully acknowledged. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nanoscale | en_US |
dc.title | Tuning mucoadhesion and mucopenetration in self-assembled poly(lactic acid)-block-poly(oligoethylene glycol methacrylate) block copolymer nanoparticles by controlling side-chain lengths | en_US |
dc.type | Article | en_US |
dc.contributor.department | Chemical Engineering | en_US |
Appears in Collections: | Student Publications (Not Graduate Theses) |
Files in This Item:
File | Description | Size | Format | |
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PLA-POEMGA_mucoadhesive_mucopenetrative_paper_RD_TH_Edit_Vf1.pdf | Manuscript | 1.46 MB | Adobe PDF | View/Open |
Supporting Information PLA-POEGMA Paper_final.pdf | Supporting Information | 1.63 MB | Adobe PDF | View/Open |
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