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http://hdl.handle.net/11375/30358
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DC Field | Value | Language |
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dc.contributor.advisor | Jordana, Manel | - |
dc.contributor.author | Phelps, Allyssa | - |
dc.date.accessioned | 2024-10-04T18:50:37Z | - |
dc.date.available | 2024-10-04T18:50:37Z | - |
dc.date.issued | 2024-11 | - |
dc.identifier.uri | http://hdl.handle.net/11375/30358 | - |
dc.description.abstract | Food allergic reactions occur when a harmless food antigen is ingested, and an unwarranted immune response is evoked. Specifically, the immune system generates IgE antibodies specific to food, which arise from long-lived allergen-specific memory B cells. The key goal of this thesis was to develop tools to detect and characterize long-lived allergen- specific memory B cells, to then be used as a biomarker to evaluate a therapy’s capacity to modify and/or eliminate these cells. In this thesis, we first developed the tools to identify rare allergen-specific B cells. We then utilized these tools to define a phenotype of allergen- specific memory B cells unique to allergy. Lastly, we used a potentially transformative treatment (anti-IL-4Rα antibodies) to interrogate whether reprogramming of these allergen- specific memory B cells from a pathogenic to a non-pathogenic cell could be achieved. Altogether this work revealed a key biomarker of IgE memory and a potential disease transformative treatment option. | en_US |
dc.language.iso | en | en_US |
dc.title | DETECTING AND ELUCIDATING THE ROLE OF TYPE 2 POLARIZED ALLERGEN-SPECIFIC MEMORY B CELLS | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Medical Sciences (Molecular Virology and Immunology Program) | en_US |
dc.description.degreetype | Dissertation | en_US |
dc.description.degree | Doctor of Philosophy (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Phelps_Allyssa_J_202409_PhDMedicalSciences.pdf | 21.18 MB | Adobe PDF | View/Open |
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