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http://hdl.handle.net/11375/30081
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DC Field | Value | Language |
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dc.contributor.advisor | Magolan, Jakob | - |
dc.contributor.author | Wong, Eleanor | - |
dc.date.accessioned | 2024-08-26T13:28:14Z | - |
dc.date.available | 2024-08-26T13:28:14Z | - |
dc.date.issued | 2024 | - |
dc.identifier.uri | http://hdl.handle.net/11375/30081 | - |
dc.description.abstract | With rising rates of antimicrobial resistance, new antibiotics are being investigated to ensure effective treatment options exist, essential for public health. Cannabinoids are a class of prenylated phenolic natural products that have been shown to possess antibiotic potential against Methicillin Resistant Staphylococcus aureus (MRSA).1, 2 Cannabigerol (CBG) a nonpsychotropic cannabinoid was explored as a promising lead for a new antibiotic candidate. CBG and over 40 analogues were synthesized in a medicinal chemistry manner to construct a structure activity relationship (SAR) study. An alumina-mediated phenol geranylation reaction was employed as a key step in the synthesis of analogues. Here we have identified novel CBG analogues with improved physiochemical properties and increased potency against MRSA. | en_US |
dc.language.iso | en | en_US |
dc.title | Synthesis and Evaluation of Cannabigerol Inspired Antimicrobial Compounds | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Chemical Biology | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Wong_Eleanor_2024June_MSc.pdf | 7.08 MB | Adobe PDF | View/Open |
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