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http://hdl.handle.net/11375/30081
Title: | Synthesis and Evaluation of Cannabigerol Inspired Antimicrobial Compounds |
Authors: | Wong, Eleanor |
Advisor: | Magolan, Jakob |
Department: | Chemical Biology |
Publication Date: | 2024 |
Abstract: | With rising rates of antimicrobial resistance, new antibiotics are being investigated to ensure effective treatment options exist, essential for public health. Cannabinoids are a class of prenylated phenolic natural products that have been shown to possess antibiotic potential against Methicillin Resistant Staphylococcus aureus (MRSA).1, 2 Cannabigerol (CBG) a nonpsychotropic cannabinoid was explored as a promising lead for a new antibiotic candidate. CBG and over 40 analogues were synthesized in a medicinal chemistry manner to construct a structure activity relationship (SAR) study. An alumina-mediated phenol geranylation reaction was employed as a key step in the synthesis of analogues. Here we have identified novel CBG analogues with improved physiochemical properties and increased potency against MRSA. |
URI: | http://hdl.handle.net/11375/30081 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Wong_Eleanor_2024June_MSc.pdf | 7.08 MB | Adobe PDF | View/Open |
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