Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/29099
Title: | Characterizing Whole-Brain Age-Associated Trajectories of R1 in Early Adulthood Using Multi-Site MRI |
Authors: | Heo, Stella (In Kyung) |
Advisor: | Bock, Nicholas |
Department: | Psychology |
Keywords: | Multi-site neuroimaging;Harmonization;Quantitative magnetic resonance imaging;Longitudinal relaxation rate;Early adulthood |
Publication Date: | 2023 |
Abstract: | Myelin facilitates efficient neural signal transmission along axons. While predominantly present in white matter, myelin is also found in smaller amounts in the outermost layer of gray matter, known as the cortex, as well as deep subcortical structures. Quantitative magnetic resonance imaging (qMRI) metrics, including longitudinal relaxation rate (R1), can report myelin levels in vivo, although these measures are often estimated and can vary depending on pulse sequences and acquisition parameters used to collect the data. Multi-site approaches can increase the statistical power and ecological validity of studies by recruiting participants from larger and more diverse samples, but considerable variability has previously been reported in qMRI estimates of myelin computed using data from different MRI scanners. Here, we assessed intra- and inter-vendor variability in R1 maps acquired at three sites using scanners from two manufacturers, General Electric (GE) and Siemens. Two ‘traveling heads’ scans, where a participant visits and completes a scan at each site, were acquired to directly assess site effects independent of biological variability. Histogram-based site-specific scaling factors determined from the ‘traveling heads’ scans were then applied to harmonize the main dataset. Before site correction, comparable inter- and intra-vendor differences were observed in both the main dataset and the ‘traveling heads’ scans. Our method of harmonization reduced the inter-site variability considerably, while remaining sensitive to age effects in R1. We then characterized age trajectories of R1 across the whole brain using linear regressions. In the age range of 16-36, age was significantly associated with mean R1s of bilateral putamen, left pallidum, and left amygdala, in line with past research. Cortical analyses also replicated earlier findings, with higher age associations in regions of the motor and lateral frontal cortices. The findings contribute to the growing research in multi-site harmonization, while providing normative estimates and trajectories of whole-brain R1s that can be referred to in future clinical studies. |
URI: | http://hdl.handle.net/11375/29099 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Heo_Stella_IK_2023Sep_MSc.pdf | 12.78 MB | Adobe PDF | View/Open |
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