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http://hdl.handle.net/11375/28999
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DC Field | Value | Language |
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dc.contributor.advisor | Gupta, Bhagwati | - |
dc.contributor.author | Jhaveri, Nikita | - |
dc.date.accessioned | 2023-10-04T14:42:04Z | - |
dc.date.available | 2023-10-04T14:42:04Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://hdl.handle.net/11375/28999 | - |
dc.description.abstract | Comparative study of homologous structures in closely related species allows the identification of changes in gene regulatory mechanisms and their impact on the evolution of developmental processes. Nematodes, the invertebrate roundworms, are well suited for such studies, especially the Caenorhabditis briggsae and its famous cousin C. elegans. These two worms diverged from a common ancestor roughly 30 million years ago, yet appear morphologically almost identical. My Ph.D. thesis has focused on a set of nuclear factors in C. briggsae that negatively regulate cell proliferation to generate the hermaphrodite-specific mating and egg-laying organ, i.e., vulva. To this end, I have taken a two-pronged approach: one, developing resources to facilitate genetic and genomic studies in this species, and two, characterizing the roles of a novel class of genes and known repressors of vulval development. My work has uncovered substantial differences in the underlying genetic networks that regulate vulva formation in C. briggsae and C. elegans. | en_US |
dc.language.iso | en | en_US |
dc.subject | Nematode | en_US |
dc.subject | Caenorhabditis briggsae | en_US |
dc.subject | Caenorhabditis elegans | en_US |
dc.subject | Transcriptional repressors | en_US |
dc.subject | Cell proliferation | en_US |
dc.title | Investigating the evolution of transcriptional repressors in the nematode Caenorhabditis briggsae | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Biology | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Candidate in Philosophy | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Jhaveri_Nikita_S_202309_PhD.pdf | 15.83 MB | Adobe PDF | View/Open |
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