Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/27947
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | MacKillop, James | - |
dc.contributor.advisor | Moulden, Heather | - |
dc.contributor.author | Marsden, Emma | - |
dc.date.accessioned | 2022-10-07T15:48:25Z | - |
dc.date.available | 2022-10-07T15:48:25Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://hdl.handle.net/11375/27947 | - |
dc.description.abstract | Purpose: The triple network model posits that the salience network (SN), default mode network (DMN), and central executive network (CEN), are essential in understanding higher cognitive function and dysfunction. These networks are affected variably across many psychiatric conditions. Previous functional magnetic resonance imaging (fMRI) research in alcohol use disorder (AUD) has found altered functional connectivity in the SN, DMN, and CEN, suggesting all three networks may be involved. The current study utilizes fMRI to investigate the association between resting-state functional connectivity in the SN, DMN, and CEN and alcohol misuse. Methods: Fifty-two heavy drinking adults completed measures of alcohol use severity and quantity, as well as a 7-minute resting state scan. Results: Linear regression was used to test if connectivity was associated with past 12-month AUD symptoms and number of heavy drinking days. Results revealed that CEN connectivity (right lateral prefrontal cortex seed co-activating with 19 clusters) was significantly associated with AUD symptoms (b = .425, p = .003), but not heavy drinking days. Post-hoc tests revealed six clusters co-activating with the CEN were associated with AUD symptoms – right middle frontal gyrus, right inferior parietal gyrus, left middle temporal gyrus, left cerebellum 7b, right cerebellum 7b, and left cerebellum 9. DMN and SN connectivity was not associated with drinking outcomes. Conclusion: These findings illustrate that connectivity within the CEN, but not the DMN or SN, is associated with alcohol use severity. Regarding the triple network model, these results suggest that altered functional connectivity in heavy drinkers is located primarily in the CEN. | en_US |
dc.language.iso | en | en_US |
dc.subject | alcohol | en_US |
dc.subject | fMRI | en_US |
dc.subject | neuroimaging | en_US |
dc.subject | resting-state | en_US |
dc.title | Resting State Functional Connectivity and Alcohol Misuse in Heavy Drinking Adults | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Neuroscience | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
dc.description.layabstract | Alcohol use disorder is a complex condition that is not yet fully understood, especially when it comes to the underlying changes in the brain. One theory suggests that individuals with mental health conditions show changes in one or more of three key networks in the brain. These networks are essential in understanding higher cognitive function and dysfunction (e.g., emotional regulation and problem solving). This theory suggests that the range of damage in these networks leads to the differences in symptoms and symptom severity that individuals experience. Prior research among alcohol users has found changes in connectivity in all three networks, suggesting they may all be involved. This study used neuroimaging to examine whether connectivity was associated with alcohol misuse. We found that connectivity in the network involved in decision-making and problem solving was associated with alcohol use severity, suggesting this network may be a useful target for new treatment strategies. | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Marsden_Emma_L_202209_Msc.pdf | 16.49 MB | Adobe PDF | View/Open |
Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.