Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/27583
Title: | The Synthesis and Antimicrobial Evaluation of Novel Sideromycins |
Authors: | Kaul, Arnav |
Advisor: | Magolan, Jakob |
Department: | Biochemistry and Biomedical Sciences |
Keywords: | Antibiotic;Siderophore;Sideromycin;Bacteria;Gram-negative;Antimicrobial Resistance |
Publication Date: | 2022 |
Abstract: | This thesis consists of two chapters, each of which is a unique research project. Chapter 1 is focused on the synthesis and biological evaluation of novel sideromycin antibiotics. Sideromycins are bifunctional “Trojan Horse” molecules that have an iron chelator “siderophore” moiety covalently bound to an antibiotic. Such molecules exploit existing bacterial mechanisms for obtaining iron from their environment. Antibiotics that would typically not pass Gram-negative membranes are allowed access via siderophore transporter proteins. This project utilized a siderophore that has not previously been used in this capacity. The synthesis and biological evaluation of multiple sideromycin conjugates is reported. Chapter 2 describes the chemical synthesis of coumarin natural products using a synthetic process recently developed in the Magolan laboratory that enables the efficient prenylation of phenols. These natural products are molecules of biological interest in various capacities but are rare and difficult to isolate from their plant sources. They have also previously been cumbersome to make via chemical synthesis. The chemistry described herein constitutes an inexpensive and efficient process to produce these compounds that is superior to previously known methods. |
URI: | http://hdl.handle.net/11375/27583 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Kaul_Arnav_202205_MScBiochemistry.pdf | 3.17 MB | Adobe PDF | View/Open |
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