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http://hdl.handle.net/11375/26816
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DC Field | Value | Language |
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dc.contributor.author | Dvorkin A | - |
dc.contributor.author | Culver KE | - |
dc.contributor.author | Waxman D | - |
dc.contributor.author | Szechtman H | - |
dc.contributor.author | Kolb B | - |
dc.date.accessioned | 2021-08-26T16:27:19Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 0955-8810 | - |
dc.identifier.issn | 1473-5849 | - |
dc.identifier.uri | http://hdl.handle.net/11375/26816 | - |
dc.description.abstract | Hormones may modulate the symptoms of obsessive-compulsive disorder (OCD), but the evidence is equivocal and not consistent across studies, with findings of hormone-associated increases and decreases of symptoms. To assess whether a strong endocrine influence on OCD exists, the effects of hypophysectomy were examined in an animal model of OCD. The model involves repeated injections of the dopamine D2/D3 receptor agonist, quinpirole, to induce locomotor sensitization and compulsive checking behavior. Intact and hypophysectomized rats were administered quinpirole (0.5 mg/kg x 6, twice weekly) or saline and compulsive checking in a large open field was measured according to a standard protocol. Results showed that in hypophysectomized animals, the development of locomotor sensitization was attenuated but the expression of quinpirole-induced compulsive checking was full-blown. Analysis of Golgi-stained neurons showed changes in spine density in Cg3 and Par1 and increased branching of apical dendrites in Cg3. It is suggested that compulsive checking could be coupled with drug-induced increases in Cg3 dendritic branching and that changes in spine density may reflect a compensatory adjustment in dopamine-innervated regions. On the basis of the animal model findings, it is concluded that the presence of OCD checking compulsions is not dependent on pituitary axis hormones. | - |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | - |
dc.subject | Animals | - |
dc.subject | Behavior, Animal | - |
dc.subject | Cerebral Cortex | - |
dc.subject | Compulsive Behavior | - |
dc.subject | Dendrites | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Hypophysectomy | - |
dc.subject | Injections, Subcutaneous | - |
dc.subject | Male | - |
dc.subject | Motor Activity | - |
dc.subject | Neuronal Plasticity | - |
dc.subject | Obsessive-Compulsive Disorder | - |
dc.subject | Pituitary Hormones | - |
dc.subject | Quinpirole | - |
dc.subject | Rats | - |
dc.subject | Rats, Long-Evans | - |
dc.subject | Receptors, Dopamine D2 | - |
dc.subject | Receptors, Dopamine D3 | - |
dc.title | Effects of hypophysectomy on compulsive checking and cortical dendrites in an animal model of obsessive-compulsive disorder | - |
dc.type | Article | - |
dc.date.updated | 2021-08-26T16:27:15Z | - |
dc.contributor.department | Psychiatry & Behavioural Neurosciences | - |
dc.date.embargo | 2022-08-26 | - |
dc.date.embargoset | 12 months | - |
dc.identifier.doi | https://doi.org/10.1097/fbp.0b013e3283095223 | - |
Appears in Collections: | Psychiatry & Behavioural Neurosciences Publications |
Files in This Item:
File | Description | Size | Format | |
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Dvorkin2008_BP-08-20R2 - Copy (1).pdf | Accepted version | 951.29 kB | Adobe PDF | View/Open |
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