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http://hdl.handle.net/11375/26795
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DC Field | Value | Language |
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dc.contributor.author | Szechtman H | - |
dc.contributor.author | Sulis W | - |
dc.contributor.author | Eilam D | - |
dc.date.accessioned | 2021-08-19T17:58:14Z | - |
dc.date.available | 2021-08-19T17:58:14Z | - |
dc.date.issued | 1998-12 | - |
dc.identifier.issn | 0735-7044 | - |
dc.identifier.issn | 1939-0084 | - |
dc.identifier.uri | http://hdl.handle.net/11375/26795 | - |
dc.description.abstract | Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with other locations in the environment or saline controls. They performed a ritual-like set of behavioral acts at these two places/objects and stopped in relatively few locales before returning to the preferred places/objects. Finally, they shifted their behavior to a new location when the object was moved there. Clomipramine (10 mg/kg, daily) postponed but did not prevent the development of the quinpirole effect. Quinpirole-induced compulsive checking may be an exaggeration of normal checking of home site in rats. Results suggest an animal model of obsessive-compulsive disorder and a role for dopamine in this disorder. | - |
dc.publisher | American Psychological Association (APA) | - |
dc.subject | Animals | - |
dc.subject | Clomipramine | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Dopamine Agonists | - |
dc.subject | Male | - |
dc.subject | Obsessive-Compulsive Disorder | - |
dc.subject | Orientation | - |
dc.subject | Quinpirole | - |
dc.subject | Rats | - |
dc.subject | Rats, Long-Evans | - |
dc.subject | Serotonin Uptake Inhibitors | - |
dc.subject | Stereotyped Behavior | - |
dc.title | Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD). | - |
dc.type | Article | - |
dc.date.updated | 2021-08-19T17:58:14Z | - |
dc.contributor.department | Psychiatry & Behavioural Neurosciences | - |
dc.identifier.doi | https://doi.org/10.1037/0735-7044.112.6.1475 | - |
Appears in Collections: | Psychiatry & Behavioural Neurosciences Publications |
Files in This Item:
File | Description | Size | Format | |
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Szechtman1998_BN_QuinpiroleInduces_bneurosFinal.pdf | Accepted version | 684.26 kB | Adobe PDF | View/Open |
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